Zon analysis of cancer stem cell metastasis in xenograft animal models y. Cancer stem cells theories and practice intechopen. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissueorgan. Stem cells and cancer stem cells, volume 1 hayat, m. Application of stem cell principles to cancer biology and the challenges of developing combination stem and cancer biology targets for therapeutics. Despite the remaining debates regarding the existence of cancer stem cells, the cancer. In addition, the book examines specific types of cancers in which cscs have been identified, including acute leukemias, retinoblastomas, melanomas, and breast, brain, ovarian, and prostate cancers.
Even as tumors expand, however, only a small fraction of all the cellsthe cancer stem cellsare responsible for. This treatment also kills the stem cells in the bone marrow. Leukemia and the discovery of cancer stem cells cscs in the history of cancer, leukemias have often been a window into larger truths about cancer in general. Advances in cancer stem cell biology informs the reader about both basic and potential clinical applications of an intriguing subpopulation of cancer cells defined in different way as cancer stem cells, cancer stem like cells, tumor maintaining cells and so on which are deeply changing some fundamental aspects of molecular and clinical oncology. I praise the editor and the authors for this wonderful endeavor, rich of provocative ideas and challenging concepts, not only for a better understanding of basic cancer biology, but also for the future. An overview of the definition and biological properties of cscscics as well as the role of these cells in determining the resistance to standard and immunebased therapies is provided. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem. Being a stem cell donor center for cancer research. Cscs play a role in not only the creation of cancer, but also in its evolution, metastasis, and recurrence.
Without preparation, stem cell donation can be frightening for sibling donors. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. In an autologous transplant, stem cells are collected from the patients blood and then reintroduced after treatment to get rid of the cancerous cells. I tell them that i am just a phd researcher and cannot suggest an avenue of treatment for medical issues. Difference between tissue specific stem cells and embryonic stem cells is explained. New finding reopens the book on colon cancer stem cells. Among the trillions of cells in our bodies, cancer represents the clonal outgrowth of a single errant cell. Unknown whether the tissue stem cell degenerates, or if a more differentiated cell reacquires stem cell phenotype. Access the cancer research week hub for content collections highlighting the landscape of challenges and opportunities that lie ahead for the field and for science as a whole. Connexon creative recognizes that the cancer stem cell field is progressing rapidly, and takes pride in providing. Cancer stem cells csc have the ability to selfrenew and are present in most tissues including breast, brain, lung, prostates, testis, ovary, esophagus, colon, and liver. Stem cells and cancer stem cells,volume 3 springerlink. The twentyeight chapters assembled in cancer stem cells the cutting edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around.
Their origin is yet to be discovered, though a series of hypotheses have been proposed in this regard. Stem cell transplants are procedures that restore bloodforming stem cells in people who have had theirs destroyed by the very high doses of chemotherapy or radiation therapy that are used to treat certain cancers bloodforming stem cells are important because they grow into different types of blood cells. Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo and radiotherapy has been the notion of cancer stem cells. Cancer stem cells cscs are a rare subset of cancer cells which have features such as the ability to. Bioengineering and cancer stem cell concept mirjana. Cancer stem cell is a progressive concept moving forward to interpret the. The recent book by laplane on cancer stem cells is a brilliantly wellcrafted introduction to the field from is a philosophical perspective.
Blood stem cells are found in the peripheral blood and the bone marrow. A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Definition of blood stem cell nci dictionary of cancer.
Within a malignant tumor or among the circulating cancerous cells of a leukemia, there can be a variety of types of cells. Cancer stem cells in breast cancer, brain tumors, certain forms of leukemia, and gastric tumor. Cancer stem cells perspectives and how to target them. Embryonic stem cells are derived from a blastocyst the blastula typical of placental mammals.
Types of stem cell transplants memorial sloan kettering. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. This book also tackles novel methodology for cancer stem cell marker identification, cancer stem cell respiration and metabolism, genetic and epigenetic mechanisms including dna methylation, and. The stem cell theory of cancer proposes that among all cancerous cells, a few act as stem cells that reproduce themselves and sustain the cancer, much like normal. An authoritative introduction to the link between stem cell biology and cancer. Defining cancer stem cells by xenotransplantation in zebrafish m. Cancer biologists believe that cancer stem cells, like other adult stem cells, can both divide into new stem cells and differentiate into more specialized cells.
The investigation and development of the cancer stem cell csc model has received much focus during these years. Cancer stem cells wiley online books wiley online library. Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells. The story behind the book about the stem cell agency the. When a child with cancer needs a stem cell transplant, we often focus so much on that childs wellbeing that we underestimate the concerns of the sibling stem cell donor. This figure illustrates 3 hypotheses of how a cancer stem cell may arise. Second part of the book covers the application of stem cells in treatment of various types of cancer by targeting cancer stem cells. The stem cell transplant coloring book this coloring book is for children with blood cancer who are coping with having a stem cell transplant. Almost daily i receive emails from people who want access to stem cell treatments.
Research has shown that cancer cells are not all the same. The leukemiainitiating cells were enriched on the basis of cell. Cancer stem cells lucie laplane harvard university press. Soon after treatment, stem cells are given to replace those that were destroyed.
So, rafii says, if you dont get rid of those few cancer stem cellseven if you kill the other 95 percent of the tumorthen the cancer is going to continue to grow. We will evaluate any other cancer treated with bone marrow or stem cell transplantation under. Since its launch in december 2012, cancer stem cell news has become a highly valued resource and provides readers with a unique compilation of cancer stem cell research findings across multiple tissue and cancer types. Feeling prepared eases fears and allows sibling donors to feel included in their ill. The idea evolved from research carried out to explain the cause of a relatively common form of blood cell cancer. First indications that cancer stem cells may exist emerged at the end of the twentieth century at about the same time embryonic stem cells were discovered in mice. It is also for brothers, sisters, friends and classmates of the young patient, and children with a parent who is having a stem cell transplant. Within the cancer population of the tumors there are cancer stem cells csc that are tumorigenic cells and are biologically distinct from other subpopulations they have two defining features. The cancer stem cell model, also known as the hierarchical model proposes that tumors are hierarchically organized cscs lying at the apex fig. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. The book also explores innovative therapeutic strategies in preclinical and clinical trials to. Californias answer was the stem cell program cirmand continuing cirm is the reason i wrote this book.
List of books and articles about stem cell research. As revealed in the bestselling 2011 book the immortal life of henrietta lacks, this is a tale of a poor black tobacco farmer who never consented to having her tissues taken but whose cancer cells. Lucie laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Cancer stem cell resistance to targeted therapy cristina. In a typical stem cell transplant for cancer very high doses of chemo are used, sometimes along with radiation therapy, to try to kill all the cancer cells. The european cancer stem cell research institute at cardiff university believes that cancer stem cells are responsible for the spread and regrowth of tumours. Principles of stem cell biology and cancer wiley online. The length of time we will consider you to be disabled depends on whether you undergo allogeneic or autologous transplantation. Provides a platform for cancer researchers to obtain new perspectives and insightful information regarding the potential role of cancer stem cells in the future of clinical oncology differing from other books on the topic, this book is a tremendous resource for both academic and clinical investigators. Chemotherapy, for instance, was shown to be effective in leukemia well before physicians had. The book builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology. The stem cell theory of cancer ludwig center stanford.
Stem cell transplants in cancer treatment national. Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells cscs from worldclass cancer research laboratories, but its twentytwo chapters also tease apart cancers vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance. Such an approach is significant since it was galen who promoted the use of logic, and in fact the full trivium, as an. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Such an approach is significant since it was galen who promoted the use of logic, and in fact the full trivium, as an integral part of the practice of medicine. How the california stem cell program is fighting your incurable disease. The first modern evidence for a role of stem cells in cancer came in 1994 with a study of human acute myeloid leukemia lapidot et al. In all 3 scenarios, the resultant cancer stem cell has lost the ability to. The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. Despite preventive mechanisms adult stem cells may accumulate mutations over the years. This book explores the role of cancer stem cells in the diagnosis, treatment, and cure of cancers.
Final twist to tale of henrietta lacks, the woman whose. The role that stem cells play in the development of cancer is also an important area. The book also explores innovative therapeutic strategies in. Essentials of cancer stem cells and conceptual modeling. The cancer stem cell model has several important clinical implications, some of which may be profound. First part of the book covers stem cells in organogenesis and regeneration of tissueorgans in model organism to humans using embryonic stem cell, cord blood stem cells, germline stem cells, and adult stem cells. Csc is characterized as a small fraction of cancer cells that have an indefinite ability for selfrenewal and pluripotency and are responsible for initiating and sustaining of the bulk of cancer.
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